Difference Between Dry Granulation And Wet Granulation Pdf

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difference between dry granulation and wet granulation pdf

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Granulation, the process of particle enlargement by agglomeration technique, is one of the most significant unit operations in the production of pharmaceutical dosage forms, mostly tablets and capsules. Granulation process transforms fine powders into free-flowing, dust-free granules that are easy to compress. Nevertheless, granulation poses numerous challenges due to high quality requirement of the formed granules in terms of content uniformity and physicochemical properties such as granule size, bulk density, porosity, hardness, moisture, compressibility, etc. Granulation process can be divided into two types: wet granulation that utilize a liquid in the process and dry granulation that requires no liquid. The type of process selection requires thorough knowledge of physicochemical properties of the drug, excipients, required flow and release properties, to name a few.

Granulation

Granulation is the process of forming grains or granules from a powdery or solid substance, producing a granular material. It is applied in several technological processes in the chemical and pharmaceutical industries. Typically, granulation involves agglomeration of fine particles into larger granules, typically of size range between 0. Less commonly, it involves shredding or grinding solid material into finer granules or pellets. The granulation process combines one or more powder particles and forms a granule that will allow tableting to be within required limits. It is the process of collecting particles together by creating bonds between them. Bonds are formed by compression or by using a binding agent.

Wet Granulation: The process of adding a liquid solution to powders involves the massing of a mix of dry primary powder particles using a granulating fluid. Typical liquids include water, ethanol and isopropanol, either alone or in combination. The liquid solution can be either aqueous-based safer or solvent-based. Water mixed into the powders can form bonds between powder particles that are strong enough to lock them together. However, once the water dries, the powders may fall apart. Therefore, water may not be strong enough to create and hold a bond. In such instances, a liquid solution that includes a binder is required.

Difference Between Dry and Wet Granulation

Dry granulation also referred to as precompression or double compression is a size enlargement process designed to improve the flow and compression characteristics of powders that would otherwise be unsuitable for compression. The process involves compaction of powder particles into large pieces or compacts which are subsequently broken down into granules to produce granules that can be further processed into dosage forms. The manufacture of tablets by dry granulation method eliminates a number of unit operations but still include milling or micronization of drugs, weighing, mixing, slugging, dry screening, lubrication, and compression of granules into tablets. For successful manufacture of tablets using dry granulation, either the active ingredient or the diluent must have sufficient inherent binding or cohesive properties. Formation of granules using dry granulation process is generally achieved either by slugging technique or roller compaction.

This white paper explains the basics of the dry granulation principle with a roller compactor. Granulation is a process in which powder particles are made to adhere to each other, resulting in larger, multi-particle entities, so called granules. If such a process is performed without adding liquids, this is called dry granulation. In dry granulation, the powder blend is compacted by applying a force onto the powder, which in general causes a considerable size enlargement. Principally there are two methods to obtain the compacts when using dry granulation: slugging and roller compaction. Slugging If a tablet press is used for the compaction process, the term slugging is used. But since particles with a small particle size do not flow well into the die of a tablet press, the results are weight differences from one tablet slug to another.

granulation theory.pdf

Granulation is a size-enlargement process by which small particles are bonded, by means of various techniques, in coherent and stable masses granules , in which the original particles are still identifiable. In wet granulation processes, the powder particles are aggregated through the use of a liquid phase called binder. A modern and rational approach in the production of granular structures with tailored features in terms of size and size distribution, flowability, mechanical and release properties, etc. By this knowledge, suitable predictive tools can be developed with the aim to choose right process conditions to be used in developing new formulations by avoiding or reducing costs for new tests. In this chapter, after introductive notes on granulation process, the phenomenological aspects involved in the formation of the granules with respect to the main process parameters are presented by experimental demonstration.

Granulation is the process of producing grains or granules. The size of a granule is typically in the range 0. This term is often used in pharmaceutical industry since granulation is the process used in the production of tablets. There are three types of granulations as dry granulation, wet granulation, and direct blending. The main difference between dry and wet granulation is that dry granulation is the formation of granules without using any liquid solution whereas wet granulation is the formation of granules by adding a granulating liquid.

There are a number of granulation technologies available to pharmaceutical manufacturers. Given the importance of granulation in the production of oral dosage forms, this article offers advice on various processes. In the pharmaceutical industry, the three most common granulation processes for solid dosage form production are wet granulation, dry granulation roll compaction and direct blending. An obvious advantage of roll compaction is that no moisture is involved in the process; it is therefore an ideal way to process compounds that are physically or chemically unstable when exposed to moisture. Dry Granulation: This process is used to form granules without using a liquid solution, because the product to be granulated may be sensitive to moisture and heat or does not compress well.

Home Production. Ankur Choudhary Print Question Forum 1 comment. Wet granulation involves the massing of a mix of dry primary powder particles using a granulating fluid.

Main Difference – Dry vs Wet Granulation

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Granulation techniques and technologies: recent progresses

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