Pdf Controllability And Observability Of Boolean Networks Arising From Biology

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This paper addresses the problems of robust-output-controllability and robust optimal output control for incomplete Boolean control networks with disturbance inputs. First, by resorting to the semi-tensor product technique, the system is expressed as an algebraic form, based on which several necessary and sufficient conditions for the robust output controllability are presented. Second, the Mayer-type robust optimal output control issue is studied and an algorithm is established to find a control scheme which can minimize the cost functional regardless of the effect of disturbance inputs. Finally, a numerical example is given to demonstrate the effectiveness of the obtained new results.

State feedback control design for Boolean networks

If the address matches an existing account you will receive an email with instructions to reset your password. If the address matches an existing account you will receive an email with instructions to retrieve your username. In order to understand the functioning of organisms on the molecular level, we need to know which genes are expressed, when and where in the organism, and to which extent. The regulation of gene expression is achieved through genetic regulatory systems structured by networks of interactions between DNA, RNA, proteins, and small molecules. As most genetic regulatory networks of interest involve many components connected through interlocking positive and negative feedback loops, an intuitive understanding of their dynamics is hard to obtain.

Skip to search form Skip to main content You are currently offline. Some features of the site may not work correctly. Cell signaling networks are often modeled using ordinary differential equations ODEs , which represent network components with continuous variables. However, parameters such as reaction rate constants are needed for ODEs are not always available or known, and discrete approaches such as Boolean networks BNs are used in such cases. BNs have been applied in the past, in particular, as means to determine network steady states.

Metrics details. Random Boolean Networks RBNs are an arguably simple model which can be used to express rather complex behaviour, and have been applied in various domains. RBNs may be controlled using rule-based machine learning, specifically through the use of a learning classifier system LCS — an eXtended Classifier System XCS can evolve a set of condition-action rules that direct an RBN from any state to a target state attractor. However, the rules evolved by XCS may not be optimal, in terms of minimising the total cost along the paths used to direct the network from any state to a specified attractor. In this paper, we present an algorithm for uncovering the optimal set of control rules for controlling random Boolean networks. We then compare the performance of this optimal rule calculator algorithm ORC and the XCS variant of learning classifier systems.

Learning versus optimal intervention in random Boolean networks

This paper gives an equivalent condition for the observability of Boolean control networks BCNs with time-variant delays in states under a mild assumption by using the graph-theoretic method under the framework of the semi-tensor product of matrices. First, the BCN under consideration is split into a finite number of subsystems with no time delays. Second, the observability of the BCN is verified by testing the observability of the so-called observability constructed path a special subsystem without time delays based on graph theory. These results extend the recent related results on the observability of BCNs. Examples are shown to illustrate the effectiveness of the results.

Identification of control targets in Boolean molecular network models via computational algebra

Metrics details. Driving Boolean networks to desired states is of paramount significance toward our ultimate goal of controlling the progression of biological pathways and regulatory networks. Despite recent computational development of controllability of general complex networks and structural controllability of Boolean networks, there is still a lack of bridging the mathematical condition on controllability to real boolean operations in a network. Further, no realtime control strategy has been proposed to drive a Boolean network.

Springer proceedings of the conference will be available for download to all conference participants for 4 weeks upon publishing. Due to delays induced by postponing deadlines, the proceedings may not be ready before the conference starts. During the conference 23rd Sept. Here, we present a model revision tool, capable of repairing inconsistent Boolean biological models. Moreover, the tool is able to confront the models, both with steady state observations, as well as time-series data, considering both synchronous and asynchronous update schemes.

This material is presented to ensure timely dissemination of scholarly and technical work. Copyright and all rights therein are retained by authors or by other copyright holders. This document was translated from BibT E X by bibtex2html.


 - Нужно сразу быть точным. У шифров-убийц обычно есть функция злопамятства - чтобы не допустить использования метода проб и ошибок. Некорректный ввод только ускорит процесс разрушения. Два некорректных ввода - и шифр навсегда захлопнется от нас на замок. Тогда всему придет конец. Директор нахмурился и повернулся к экрану. - Мистер Беккер, я был не прав.

На этот раз послышались длинные гудки. Фонтейн насчитал уже шесть гудков. Бринкерхофф и Мидж смотрели, как он нервно шагает по комнате, волоча за собой телефонный провод. Директор АНБ напоминал тигра на привязи. Лицо его все сильнее заливалось краской. - Невероятно! - воскликнул он и снова швырнул трубку.


Если бы Сьюзан не была парализована страхом, она бы расхохоталась ему в лицо. Она раскусила эту тактику разделяй и властвуй, тактику отставного морского пехотинца. Солги и столкни лбами своих врагов.

Стоя на ковре возле письменного стола, она в растерянности осматривала кабинет шефа. Комнату освещали лишь странные оранжевые блики. В воздухе пахло жженой пластмассой. Вообще говоря, это была не комната, а рушащееся убежище: шторы горели, плексигласовые стены плавились.

Мидж стояла на своем: - Но, сэр. Коммандер Стратмор обошел систему Сквозь строй. Фонтейн подошел к ней, едва сдерживая гнев.


  1. Garland C. 24.12.2020 at 11:33

    Many problems in biomedicine and other areas of the life sciences can be characterized as control problems, with the goal of finding strategies to change a disease or otherwise undesirable state of a biological system into another, more desirable, state through an intervention, such as a drug or other therapeutic treatment.

  2. Kyle C. 27.12.2020 at 02:03

    A salient problem in systems biology is to develop a control theory for complex and nonlinear biological systems. A number of mathematical models have been.

  3. Flordelis B. 27.12.2020 at 16:34

    A salient problem in systems biology is to develop a con- trol theory for complex and nonlinear biological systems. A number of mathematical models have been.

  4. Taisalubee 29.12.2020 at 14:53

    In this paper, we present a systematic transition scheme for a large class of ordinary differential equations ODEs into Boolean networks.

  5. Enamorarse 30.12.2020 at 03:45

    of Boolean control networks (BCNs) has been open for five years already. out that “One of the major goals of systems biology is to develop a Boolean networks arising from biology, Chaos: An Interdisciplinary. Journal of.